Senior Director, GCS Early Pipeline and Business Development

Job Description

General Summary

The Senior Director or Director, GCS Early Pipeline and Business Development will serve as the global commercial lead for two priority pre-clinical diseases in the Vertex Sandbox. These diseases have been prioritized for potential advancement through internal research and external innovation. The role will build the deep commercial understanding required to guide research choices, evaluate future assets, and enable rapid, informed development decisions when a program is ready to enter the clinic.

This leader will represent Commercial on the early Disease Strategy Teams (eDSTs) for the assigned diseases and own the commercial opportunity assessment and disease strategy. The role will develop a detailed view of the market today and how it may evolve, translate the opportunity into market value by geography and patient segment, and build revenue forecasts for both the future asset and broader market. The goal is to establish a clear commercial north star and target product profile before asset-specific development decisions are made.

Key Duties & Responsibilities

• Serve as the global commercial lead and eDST Commercial representative for two assigned pre-clinical Sandbox diseases, owning the commercial assessment, disease strategy, and recommendations for advancement.
• Build a comprehensive understanding of each disease, including etiology and pathophysiology, epidemiology, diagnosis, patient heterogeneity, disease burden, unmet need, clinical practice, treatment guidelines, patient journey, and intervention points.
• Develop a rigorous view of the current and future market, including diagnosed and addressable populations, treatment rates, market evolution, future standards of care, competitive entry, pricing and access assumptions, and commercialization potential by geography and patient segment.
• Own market sizing, valuation, and forecasting for the assigned diseases, creating transparent bottom-up models that quantify the market today and in the future by geography and patient segment, translate the opportunity into market value, and forecast revenue for both the future asset and broader market.
• Lead primary market research with healthcare professionals, patients, caregivers, payers, and other stakeholders, including qualitative and quantitative research, advisory boards, and expert engagement.
• Integrate insights from analytics, claims and other real-world data, competitive intelligence, epidemiology, market access, HEOR, scientific literature, and external experts into a fact-based commercial perspective.
• Define the commercial requirements for a successful product, including target populations, desired positioning, meaningful clinical outcomes, differentiation thresholds, evidence needs, formulation and administration considerations, and access requirements.
• Develop and maintain disease-level and asset-relevant target prod...

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