Vice President, IT Resilience & Trust

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Vice President, IT Resilience & Trust is a strategic and operational technology executive responsible for ensuring Madrigal’s technology environment is reliable, resilient, secure, compliant, and able to scale with the business.

As Madrigal continues to grow, expand internationally, and adopt new technologies at increasing speed, the technology foundation supporting the company is becoming more complex, interconnected, and critical to business performance. This leader will bring together Infrastructure & Reliability, Cybersecurity, and Technology Compliance under an integrated Resilience & Trust organization and will establish the strategies, operating practices, capabilities, standards, and controls needed to support Madrigal’s continued growth.

Reporting to the Chief Information Officer, this is a senior IT leadership role with accountability spanning both strategy and execution. The Vice President will lead the functional leaders responsible for Infrastructure, Cybersecurity, and Technology Compliance while establishing an integrated operating model across these domains.

This leader will establish a disciplined management system across Resilience & Trust, using service, reliability, risk, security, compliance, and resilience data to identify trends, make investment decisions, manage performance, and drive continuous improvement.

Working across the IT Leadership Team, the Vice President will establish practical standards and guardrails that allow Madrigal to innovate and scale with confidence. This includes partnering closely with technology and business leaders to ensure cybersecurity, compliance, resilience, and technology risk requirements are embedded into architecture, delivery, operations, emerging technologies, and AI-enabled capabilities without creating unnecessary friction.

As Madrigal expands globally, this executive will establish a repeatable technology foundation and operating model that enables new markets to launch consistently, efficiently, effectively, and safely.

Key Responsibilities

Resilience & Trust Strategy

• Define and execute Madrigal’s integrated Resilience & Trust strategy and multi-year roadmap across infrastructure, cybersecurity, technology compliance, service management, and resilience.
• Translate business growth, international expansion, regulatory requirements, technology trends, and emerging risks into clear priorities, standards, roadmaps, and investment decisions.
• Establish target architectures, operating principles, and risk-based technology guardrails that enable speed and innovation while maintaining appropriate reliability, security, compliance, and resilience.
• Partner with AI, digital, data, and other technology leaders to establish practical control, security, monitoring, and assurance expectations, and develop a repeatable technology foundation for global expansion.
• Establish a data-driven operating cadence across Resilience & Trust, manage investment tradeoffs, and serve as a trusted advisor to the CIO and IT Leadership Team on material risks, dependencies, priorities, and decisions.

Infrastructure & Reliability

• Provide executive leadership for infrastructure, workplace technology, enterprise service management, and technology operations, ensuring services are reliable, scalable, secure, resilient, and aligned with business needs.
• Define and evolve the strategy for cloud, networks, workplace, identity and access, endpoints, collaboration, and other foundational technology services.
• Build an enterprise-grade service management model that gives employees a consistent way to obtain technology support and establishes common ITSM practices across infrastructure, applications, digital products, data platforms, and key providers.
• Mature the ITSM platform, service ownership model, CMDB/service mapping, and core disciplines including incident, problem, change, request, knowledge, configuration, and service-level management.
• Establish measurable service levels, customer experience measures, observability, and operational health metrics, using performance data and root-cause analysis to improve reliability, reduce technical debt, and drive continuous improvement.
• Own technology resilience and major incident management, including disaster recovery, RTO/RPO, dependency mapping, testing, cross-functional recovery coordination, and execut...

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