VP, Commercial & Medical Affairs IT Business Partner

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Vice President, Commercial & Medical Affairs IT Business Partner will lead Madrigal’s Commercial and Medical Affairs IT Business Partnership, supporting the company’s global Commercial and Medical Affairs organizations. This role will serve as the senior IT partner to the Commercial and Medical Affairs executive leadership teams, translating functional strategy into technology roadmaps, portfolio priorities, operating capabilities, and delivery outcomes.

As Madrigal continues to scale as a commercial-stage company, the technology needs across Commercial and Medical Affairs are becoming more complex, interconnected, global, and critical to the company’s ability to execute. This leader will help mature how IT supports the customer, patient, provider, payer, and medical engagement ecosystem, ensuring the right systems, data, integrations, processes, partners, and internal capabilities are in place to support commercial execution, market access, patient services, field effectiveness, omnichannel engagement, medical education, field medical excellence, and continued operational scale.

This is a senior leadership role that requires deep life sciences technology experience, strong executive influence, and the ability to operate across strategy and execution. The VP will own the Commercial and Medical Affairs IT portfolio, budget, roadmap, application landscape, and business partnership model, while working closely with Data, AI, Cybersecurity, Enterprise Architecture, Infrastructure, PMO, and IT Compliance to ensure solutions are scalable, compliant, secure, and aligned to enterprise standards.

A key part of this role will be helping Commercial and Medical Affairs use technology, data, automation, and AI to scale more effectively. Commercial and Medical Affairs are both high-value, high-complexity areas where technology decisions directly affect business execution, customer engagement, patient access, field productivity, insight generation, and compliance. This leader will partner with business leaders to anticipate how evolving strategies, operating models, field needs, data requirements, and global growth affect the technology roadmap, and translate those needs into practical, durable technology plans.

Key Responsibilities

Commercial and Medical Affairs IT Strategy & Executive Partnership

• Serve as the senior IT business partner for Madrigal’s Commercial and Medical Affairs organizations, building trusted relationships with the respective ELT members and their leadership teams.
• Translate Commercial and Medical Affairs business strategies into multi-year technology roadmaps, investment priorities, and portfolio plans.
• Provide strategic technology guidance across Commercial and Medical Affairs capabilities, including sales, marketing, market access, patient services, commercial operations, sales operations, forecasting, insights and analytics, incentive compensation, training, digital, omnichannel, medical information, medical communications, publications, field medical, medical operations, grants, investigator-initiated trials, KOL engagement, congresses, and related business capabilities.
• Partner with business leaders to identify opportunities where technology, data, automation, and AI can improve speed, effectiveness, customer engagement, patient access, field productivity, compliance, visibility, and decision-making.
• Represent Commercial and Medical Affairs needs within ITLT and enterprise governance forums, ensuring business priorities are visible, well-understood, and appropriately sequenced.
• Navigate competing priorities across Commercial and Medical Affairs, facilitating balanced recommendations that align with enterprise and corporate objectives.
• Ensure global Commercial and Medical Affairs technology needs are represented in enterprise planning, while recognizing that the U.S. business is the primary near-term driver of scale and complexity.

Portfolio, Roadmap & Investment Leadership

• Own the Commercial and Medical Affairs IT portfolio globally, including roadmap development, investment planning, prioritization, and value realization.
• Partner with PMO and IT leadership to ensure initiatives are appropriately scoped, sequenced, resourced, governed, and delivered.
• Develop clear business cases for technology investments, including expected value, risk, implementation approach, resource needs, and long-term operating implications.
• Make start / stop / sequence recommendations for Commercial and Medical Affairs IT initiatives based on business value, risk, capacity, dependencies, and strategic alignment.
• Ensure Commercial and Medical Affairs IT roadmaps are realistic, integrated, and aligned with enterprise architecture, data strategy, cybersecurity, infrastructure, and compliance expectations.
• Provide executive-level visibility into portfolio health, delivery risks, resource constraints, and key decisions needed to keep work moving.
• Ensure te...

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.

Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis.