Associate Scientist, AAV Vector Production
Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.
Position
We are seeking an exceptional Associate Scientist with hands-on expertise in adeno-associated virus (AAV) vector production, purification, and analytical characterization to join our team. In this role, you will contribute end-to-end to the generation of high-quality, well-characterized AAV lots that enable both rodent and non-human primate (NHP) in vivo studies. You will scale transient transfection, optimize downstream purification processes (affinity chromatography, ion exchange, tangential-flow filtration), and perform key characterization assays (qPCR/ddPCR, ELISA, HPLC, SDS-PAGE, western blot, CGE, endotoxin, sterility). You will be responsible for processing ex-vivo tissues and preparing samples for NG...
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