Scientist/Sr. Scientist, Pre-clinical Pharmacology (Neuroscience & Metabolism)

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

We are seeking a PhD-level scientist to run preclinical pharmacology and target validation studies for our neuroscience and metabolic programs, with a focus on siRNA and oligonucleotide therapeutics. This is a hands-on lab role. You will execute  vivo studies, run the downstream assays that show whether a target is engaged and a therapeutic is working, and turn that data into clear answers for the team. Our work centers on neurodegenerative diseases, obesity and cardiometabolic disease across adipose, liver, and heart, with some programs touching the neural regulation of energy balance

You’ll join a team that moves with the speed and conviction of a biotech, working closely with discovery, translational, and external partners to advance novel therapeutics. We will consider candidates at the Scientist or Senior Scientist level, depending on experience.

Responsibilities

• Design, execute, interpret, and communicate preclinical pharmacology studies, providing clear recommendations that infor...

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